Insights That Move the GPCR Field Forward

Dr. Jens Carlsson reveals how predictive modeling is reshaping GPCR drug discovery—bridging computation, chemistry, and pharmacology for real-world impact.

The difference between orthosteric vs. allosteric mechanisms isn’t just academic — an orthosteric antagonist can hijack receptor physiology, while an allosteric modulator works with the system. That choice determines whether you risk over- or under-dosing, miss safety windows, or miss therapeutic breakthroughs.