Hello GPCR Minds,   This week, you'll learn all about Terry’s Pharmacology Corner, your new learning space focused on GPCR pharmacology. Whether you’re early in your career or pushing the edge of MoA design, weekly lesson help you apply key concepts like binding, signaling, and kinetics in practical, decision-shaping ways. The Corner comes will live monthly AMA sessions with Dr. Kenakin. Get curated content at your own pace.   Subscribe to The Kenakin Brief below to stay in t

Hello GPCR Trailblazers, This week, we’re spotlighting Celtarys Research, our newest partner, featured in a blog and podcast with CSO Dr. Maria Majellaro, highlighting their fluorescent ligand tools for live-cell GPCR assays.   After 40+ years and 250 publications, Dr. Terry Kenakin is launching a new learning space with video courses, AMAs, and practical insights . Get a sneak peek  and sign up for The Kenakin Brief—his free weekly newslette r.   On the industry side, Novo N

Celtarys Research Joins Dr. GPCR – Precision Tools for GPCR Assays Dr. GPCR and Celtarys Research have teamed up. This partnership aims to bring advanced chemical probe strategies to the forefront. The goal is to accelerate receptor-targeted discovery. They will showcase innovative conjugation methods. These methods will provide scientists with direct access to emerging tools and insights. Explore the partnership Multiplexing GPCR Discovery - Sakmar Lab’s Toolkit Goes Publi

Dr. GPCR, the global knowledge hub for G protein-coupled receptor (GPCR) research and education, is proud to welcome Celtarys Research to its partner ecosystem. This collaboration aims to amplify the visibility and adoption of Celtarys’ cutting-edge fluorescent ligand technology and accelerate the development of GPCR-targeted therapeutics.

Hi GPCR Enthusiasts (and Arrestin Aficionados!)   This week at Dr. GPCR, we’re decoding arrestin-driven signaling and spotlighting the tools to match.   Check out our new on-demand course on non-canonical GPCR behaviors and a podcast episode tracing 30 years of GPCR-RAMP discovery. Additionally, new studies reveal how phosphorylation barcodes shape arrestin engagement, a biased NTSR1 modulator targets pain without the need for opioids, and a real-time lipid probe tracks early

GPCR Colleagues & Curiosity-Driven Minds, We’re starting with exciting Dr. GPCR updates: sharpen your skills with our new on-demand course, Techniques for Effective Lead Optimization with Dr. Terry Kenakin, and catch up on cutting-edge insights through our full library of symposia recordings, now available with your Premium Membership.   We’re also spotlighting breakthroughs that challenge dogma and deepen our view of receptor dynamics, from the surprising discovery that β-a

Hello Sweet GPCR Enthusiasts, This week at Dr. GPCR: a new podcast episode with Dr. Ben Clements, a tour of our official Dr. GPCR Store, and a spotlight on the cryo-EM structure of the sweet taste receptor.   We’re also tracking biased signaling in Class B GPCRs, the membrane-driven modulation of mGluR2, and a big headline, Novo Nordisk’s $2.2B deal with Septerna to develop GPCR-targeted obesity therapeutics.  Scroll down for the science, the strategy, and the sweet stuff 🍬

Hello GPCR Colleagues and Collaborators, We’re diving into May with serious momentum. This week brings sharp new insights into how minor changes in ligand structure can flip GPCR function, how ACKR3 modulates cardiac lymphatic repair, and how β-arrestins decode GPCR phosphorylation barcodes. Plus, check out the latest Dr. GPCR tools and key moves in the biotech world. Dr. GPCR Updates   We want your feedback - Help shape the future of Dr. GPCR.   Your voice matters. Every ins

Ho, ho, ho, GPCR elves! As the year wraps up, we're thrilled to present the final edition of the GPCR Weekly Newsletter for 2024! As researchers, we all understand the importance of data in driving meaningful discoveries  and advancing our experiments.   At Dr. GPCR, we believe the same principle applies to building a better experience  for our online community.   We’d love to hear your thoughts on our website and its features  so that we can continue to support your work and

Hello, hello GPCR Buddies! It's starting to look a lot like Christmas at Dr. GPCR! We've got an early holiday treat for you: The University CheatSheet ! Dive into our courses, talks, poster presentations, and more! This Week’s Highlights: Congratulations to our amazing Board Member JoAnn Trejo for being elected to the British Pharmacological Society Honorary Fellowship! 🎉 Conformational coupling between extracellular and transmembrane domains modulates holo-adhesion GPCR

Grab your flux capacitors, GPCR time travelers! We're zooming back to the future of GPCR discoveries. Buckle up as we time-hop through this week's GPCR escapade! This Week’s Highlights: G protein-coupled receptor (GPCR) pharmacogenomics Miles D Thompson , David Reiner-Link , Alessandro Berghella , Brinda K Rana , G Enrico Rovati , Valerie Capra , Caroline M Gorvin , Alexander S Hauser Calcineurin-fusion facilitates cryo-EM structure determination of a Family A GPCR Jun Xu , G

Greetings, GPCR Colleague! Prepare to be amazed! Shocking GPCR revelations await you. Explore the newest breakthroughs and thrilling research findings in this week's update! This Week’s Highlights: Celebrating Excellence:   Patrick Sexton  and Arthur Christopoulos  Named Among Top 1% of Scientists in Pharmacology and Toxicology for 2024 ! High-affinity agonists reveal recognition motifs for the MRGPRD GPCR Chunyu Wang ,  Yongfeng Liu ,  Marion Lanier ,   Brian K Shoichet ,  E

Hoist the sails, GPCR sailors! The GPCR ship is setting sail on a grand voyage across the vast ocean of research. Dive in and explore the depths in this week's GPCR update! This Week’s Highlights: SNX9 family mediates βarrestin-independent GPCR endocytosis Valeria Robleto , Ya Zhuo , Joseph Crecelius , Sara Benzow , Adriano Marchese Cannabinoid regulation of angiotensin II-induced calcium signaling in striatal neurons Rafael Rivas-Santisteban , Ana Muñoz , Jaume Lillo , Iu Ra

Hey there, curious minds! Want to know what’s buzzing in the world of GPCRs? Join us for this week’s update, where you’ll find all the latest breakthroughs and exciting developments in GPCR research. We can’t wait to share it with you! This Week’s Highlights: Harnessing Deep Mutational Scanning for Enhanced Drug Discovery Cam Sinh Lu GPCR-BSD: a database of binding sites of human G-protein coupled receptors under diverse states Fan Liu , Han Zhou , Xiaonong Li , Liangliang Zh

Get your space suits on, GPCR cadets! The GPCR rocket is all fueled and ready to blast off into a galaxy of incredible advancements, now powered up with a series of cosmic GPCR events for the year ahead. It’s time to mark your calendars and save the dates—let’s make some stellar memories together! 🚀✨ This Week’s Highlights: Congrats to: Ya-Tzu Li , our notable contributor, for her superb undergrad paper along with Hao-Jen Hsu , Chun-Chun Chang , et al.   about State transi

Get ready for an expedition, GPCR explorers! Embark on another exciting exploration of the unknown realms of GPCR research. Welcome back to your weekly GPCR quest! This Week’s Highlights: Congrats to: John Teye Azietaku , our great contributor, for his article Class B1 GPCR Dimerization: Unveiling Its Role in Receptor Function and Signaling Sonja Peter , Brian Bender , Chris De Graaf   for their excellent work on Comparative Study of Allosteric GPCR Binding Sites and Their Li

Get ready for an expedition, GPCR explorers! Embark on another exciting exploration of the unknown realms of GPCR research. Welcome back to your weekly GPCR quest! This Week’s Highlights: Congrats to: John Teye Azietaku , our great contributor, for his article Class B1 GPCR Dimerization: Unveiling Its Role in Receptor Function and Signaling Sonja Peter , Brian Bender , Chris De Graaf for their excellent work on Comparative Study of Allosteric GPCR Binding Sites and Their Lig

Hey there, GPCR Enthusiasts! Ready for your GPCR quest, so bold and bright? Join us now, and let's explore with all our might! 🎇 This Week’s Highlights: Congrats to: Remi Janicot , and Mikel Garcia-Marcos for their excellent work on Protocol to investigate G protein-coupled receptor signaling kinetics and concentration-dependent responses using ONE-GO biosensors Why wait any longer to sign up for Principles of Pharmacology II ? Act fast to secure your place in our upcoming

Hey there, GPCR Enthusiasts! Are you geared up for your GPCR fix of the day? Get ready to dive into some discoveries and mind-blowing breakthroughs with us! This Week’s Highlights: Congrats to: Our contributor, Cam Sinh Lu ,  who has just released an incredible article on our site and a GPCR Paper with his team: Targeted Drug Design through GPCR Mutagenesis: Insights from β2AR China M Payne ,   Cam Sinh Lu ,   Karen Gregory ,  Lauren May ,  Andrea Vernall , et al. for their f

Welcome aboard, GPCR Crew! Let's set sail towards exciting discoveries and groundbreaking achievements together! This Week’s Highlights: Our fearless leader, Yamina Berchiche , is gearing up to rock the mic today at the 22nd Discovery on Target ! We're sending you all the good vibes and a sprinkle of birthday magic for an epic celebration! 🚀🎉 Kilian Roßmann , Joshua Levitz , Johannes Broichhagen for their excellent work on Deuteration as a General Strategy to Enhance Azobe

Ahoy, GPCR Crew! Instead of just staying up to date, dive in, broaden your knowledge, and pave the way in the fantastic world of the GPCR field! This Week’s Highlights: Celebrating Excellence: Hyoungjun Ham , Yamina Berchiche , Thomas Sakmar , Vladimir Katanaev , Helen Su , et al. for their fantastic work on Germline mutations in a G protein identify signaling cross-talk in T cells Victoria Saca , Colin Burdette , and Thomas Sakmar for their excellent study on GPCR Biosens

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We hope you had a fantastic Labor Day! We’re thrilled to bring you the latest updates from the GPCR world, including some exciting news...