This week's breakthroughs are crucial for staying ahead in the rapidly evolving landscape of GPCR research and drug discovery. Dr. Terry Kenakin's insights on target residence time can reshape how you evaluate and advance lead compounds, potentially saving your team from costly late-stage failures. That's exactly what Dr. GPCR delivers every week: practical tools and critical intelligence to elevate your science and sharpen your decisions.

In pharmacology, the wrong interpretation of antagonist behavior can derail your conclusions, your experiments, and even your program’s credibility. That’s why mastering competitive vs non-competitive antagonism isn’t optional — it’s essential for accurate, defensible science. This week’s Terry’s Corner takes you beyond curve shapes into the kinetic and mechanistic realities that separate surface-level analysis from true expertise.

This week's Terry's Corner with Dr. Terry Kenakin delivers a game-changing framework for teams grappling with the gap between in vitro potency and in vivo performance.

Allostery isn’t just an advanced concept—it’s essential to understanding efficacy, ligand bias, and receptor behavior in real-world systems.

Welcome GPCR Fans, Every discovery-phase decision you make shapes your entire pipeline trajectory—and understanding when equilibrium...

That’s why this week at Dr. GPCR, we’re focusing on the hidden risks that undermine progress and how the right frameworks can keep your pipeline moving forward.

The latest Terry’s Corner unlocks clinical forecasting tools few scientists truly master.

Welcome Back, Discovery Drivers Terry’s Corner is live, on-demand pharmacology built for drug discovery. Yamina’s Corner opens for strategic consulting, and our partner Celtarys unveils a robust TR-FRET assay for CBRs. Plus: must-read chemokine and PTH1R papers, and new momentum across biotech—from Superluminal to Neurocrine to novel GLP-1 contenders. Dr.GPCR Updates Terry’s Corner is Live - Pharmacology at your fingertips Terry’s Corner is now open! Explore 10 on-demand l

Terry’s Corner — a new platform where GPCR scientists can sharpen their thinking, expand their toolkit, and learn directly from Dr. Terry Kenakin. Ten on-demand courses are live now, built to challenge assumptions and bring clarity to the complex, evolving world of GPCR pharmacology.

Hello GPCR Innovators , We’re preparing to launch Terry’s Corner, a new knowledge hub shaped by Dr. Terry Kenakin’s decades of GPCR insight. It will bridge foundational receptor theory with today’s most pressing pharmacological questions, from biased signaling to allosteric design. Meanwhile, incretin and amylin-based therapies are reshaping the obesity drug landscape. Novo Nordisk’s amycretin showed up to 24% weight loss, CagriSema delivered 22.7% in Phase 3, and semaglu

Hello GPCR Minds, This week, you'll learn all about Terry’s Pharmacology Corner, your new learning space focused on GPCR pharmacology. Whether you’re early in your career or pushing the edge of MoA design, weekly lesson help you apply key concepts like binding, signaling, and kinetics in practical, decision-shaping ways. The Corner comes will live monthly AMA sessions with Dr. Kenakin. Get curated content at your own pace. Subscribe to The Kenakin Brief below to stay in t

Hello GPCR Trailblazers, This week, we’re spotlighting Celtarys Research, our newest partner, featured in a blog and podcast with CSO Dr. Maria Majellaro, highlighting their fluorescent ligand tools for live-cell GPCR assays. After 40+ years and 250 publications, Dr. Terry Kenakin is launching a new learning space with video courses, AMAs, and practical insights . Get a sneak peek and sign up for The Kenakin Brief—his free weekly newslette r. On the industry side, Novo N

Celtarys Research Joins Dr. GPCR – Precision Tools for GPCR Assays Dr. GPCR and Celtarys Research have teamed up. This partnership aims to bring advanced chemical probe strategies to the forefront. The goal is to accelerate receptor-targeted discovery. They will showcase innovative conjugation methods. These methods will provide scientists with direct access to emerging tools and insights. Explore the partnership Multiplexing GPCR Discovery - Sakmar Lab’s Toolkit Goes Publi

Dr. GPCR, the global knowledge hub for G protein-coupled receptor (GPCR) research and education, is proud to welcome Celtarys Research to its partner ecosystem. This collaboration aims to amplify the visibility and adoption of Celtarys’ cutting-edge fluorescent ligand technology and accelerate the development of GPCR-targeted therapeutics.

Hi GPCR Enthusiasts (and Arrestin Aficionados!) This week at Dr. GPCR, we’re decoding arrestin-driven signaling and spotlighting the tools to match. Check out our new on-demand course on non-canonical GPCR behaviors and a podcast episode tracing 30 years of GPCR-RAMP discovery. Additionally, new studies reveal how phosphorylation barcodes shape arrestin engagement, a biased NTSR1 modulator targets pain without the need for opioids, and a real-time lipid probe tracks early

GPCR Colleagues & Curiosity-Driven Minds, We’re starting with exciting Dr. GPCR updates: sharpen your skills with our new on-demand course, Techniques for Effective Lead Optimization with Dr. Terry Kenakin, and catch up on cutting-edge insights through our full library of symposia recordings, now available with your Premium Membership. We’re also spotlighting breakthroughs that challenge dogma and deepen our view of receptor dynamics, from the surprising discovery that β-a

Hello Sweet GPCR Enthusiasts, This week at Dr. GPCR: a new podcast episode with Dr. Ben Clements, a tour of our official Dr. GPCR Store, and a spotlight on the cryo-EM structure of the sweet taste receptor. We’re also tracking biased signaling in Class B GPCRs, the membrane-driven modulation of mGluR2, and a big headline, Novo Nordisk’s $2.2B deal with Septerna to develop GPCR-targeted obesity therapeutics. Scroll down for the science, the strategy, and the sweet stuff 🍬

Hello GPCR Colleagues and Collaborators, We’re diving into May with serious momentum. This week brings sharp new insights into how minor changes in ligand structure can flip GPCR function, how ACKR3 modulates cardiac lymphatic repair, and how β-arrestins decode GPCR phosphorylation barcodes. Plus, check out the latest Dr. GPCR tools and key moves in the biotech world. Dr. GPCR Updates We want your feedback - Help shape the future of Dr. GPCR. Your voice matters. Every ins

Ho, ho, ho, GPCR elves! As the year wraps up, we're thrilled to present the final edition of the GPCR Weekly Newsletter for 2024! As researchers, we all understand the importance of data in driving meaningful discoveries and advancing our experiments. At Dr. GPCR, we believe the same principle applies to building a better experience for our online community. We’d love to hear your thoughts on our website and its features so that we can continue to support your work and

Hello, hello GPCR Buddies! It's starting to look a lot like Christmas at Dr. GPCR! We've got an early holiday treat for you: The University CheatSheet ! Dive into our courses, talks, poster presentations, and more! This Week’s Highlights: Congratulations to our amazing Board Member JoAnn Trejo for being elected to the British Pharmacological Society Honorary Fellowship! 🎉 Conformational coupling between extracellular and transmembrane domains modulates holo-adhesion GPCR

Grab your flux capacitors, GPCR time travelers! We're zooming back to the future of GPCR discoveries. Buckle up as we time-hop through this week's GPCR escapade! This Week’s Highlights: G protein-coupled receptor (GPCR) pharmacogenomics Miles D Thompson , David Reiner-Link , Alessandro Berghella , Brinda K Rana , G Enrico Rovati , Valerie Capra , Caroline M Gorvin , Alexander S Hauser Calcineurin-fusion facilitates cryo-EM structure determination of a Family A GPCR Jun Xu , G

Greetings, GPCR Colleague! Prepare to be amazed! Shocking GPCR revelations await you. Explore the newest breakthroughs and thrilling research findings in this week's update! This Week’s Highlights: Celebrating Excellence: Patrick Sexton and Arthur Christopoulos Named Among Top 1% of Scientists in Pharmacology and Toxicology for 2024 ! High-affinity agonists reveal recognition motifs for the MRGPRD GPCR Chunyu Wang , Yongfeng Liu , Marion Lanier , Brian K Shoichet , E

Hoist the sails, GPCR sailors! The GPCR ship is setting sail on a grand voyage across the vast ocean of research. Dive in and explore the depths in this week's GPCR update! This Week’s Highlights: SNX9 family mediates βarrestin-independent GPCR endocytosis Valeria Robleto , Ya Zhuo , Joseph Crecelius , Sara Benzow , Adriano Marchese Cannabinoid regulation of angiotensin II-induced calcium signaling in striatal neurons Rafael Rivas-Santisteban , Ana Muñoz , Jaume Lillo , Iu Ra

Hey there, curious minds! Want to know what’s buzzing in the world of GPCRs? Join us for this week’s update, where you’ll find all the latest breakthroughs and exciting developments in GPCR research. We can’t wait to share it with you! This Week’s Highlights: Harnessing Deep Mutational Scanning for Enhanced Drug Discovery Cam Sinh Lu GPCR-BSD: a database of binding sites of human G-protein coupled receptors under diverse states Fan Liu , Han Zhou , Xiaonong Li , Liangliang Zh