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Insights That Move the GPCR Field Forward
Read the latest analyses, interviews, and discoveries shaping the GPCR ecosystem — from research breakthroughs to biotech strategy.
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GPCR Papers
GPCR Papers features curated selections of cutting-edge research advancing receptor biology, pharmacology, and therapeutic innovation. Each post highlights the studies shaping our understanding of GPCRs and their impact across discovery and translational science.
Identification of A2BAR as a potential target in colorectal cancer using novel fluorescent GPCR...
October 2022 Identification of A2BAR as a potential target in colorectal cancer using novel fluorescent GPCR ligands "G-protein coupled...
GPCR News
Sep 30, 20221 min read
GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for...
October 2022 GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for the A2A Adenosine Receptor...
GPCR News
Sep 30, 20221 min read
Endogenous ligand recognition and structural transition of a human PTH receptor
October 2022 "Endogenous parathyroid hormone (PTH) and PTH-related peptide (PTHrP) bind to the parathyroid hormone receptor 1 (PTH1R) and...
GPCR News
Sep 30, 20221 min read
Coincident Regulation of PLCβ Signaling by Gq-Coupled and μOpioid Receptors Opposes Opioid- Mediated
October 2022 Coincident Regulation of PLCβ Signaling by Gq-Coupled and μOpioid Receptors Opposes Opioid- Mediated Antinociception "Pain...
GPCR News
Sep 30, 20221 min read
Intermolecular Interactions in G Protein-Coupled Receptor Allosteric Sites at the Membrane Interface
October 2022 Intermolecular Interactions in G Protein-Coupled Receptor Allosteric Sites at the Membrane Interface from Molecular Dynamics...
GPCR News
Sep 30, 20221 min read
ADGRL3 genomic variation implicated in neurogenesis and ADHD links functional effects to the...
October 2022 ADGRL3 genomic variation implicated in neurogenesis and ADHD links functional effects to the incretin polypeptide GIP...
GPCR News
Sep 30, 20221 min read
Adenosine receptor signalling in Alzheimer's disease
October 2022 "Alzheimer's disease (AD) is the most common dementia in the elderly and its increasing prevalence presents treatment...
GPCR News
Sep 30, 20221 min read
Glucagon receptor-mediated regulation of gluconeogenic gene transcription is endocytosis-dependent..
October 2022 Glucagon receptor-mediated regulation of gluconeogenic gene transcription is endocytosis-dependent in primary hepatocytes "A...
GPCR News
Sep 30, 20221 min read
Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin...
October 2022 Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial...
GPCR News
Sep 30, 20221 min read
Mechanistic Understanding of the Palmitoylation of Go Protein in the Allosteric Regulation of...
October 2022 Mechanistic Understanding of the Palmitoylation of Go Protein in the Allosteric Regulation of Adhesion Receptor GPR97...
GPCR News
Sep 30, 20221 min read
Production of human A2AAR in lipid nanodiscs for 19F-NMR and single-molecule fluorescence...
October 2022 "We describe production of the human A2A adenosine receptor (A2AAR), a class A G protein-coupled receptor (GPCR) for 19F-NMR...
GPCR News
Sep 30, 20221 min read
Activation of GPR183 by 7 α,25-Dihydroxycholesterol Induces Behavioral Hypersensitivity through...
October 2022 Activation of GPR183 by 7 α,25-Dihydroxycholesterol Induces Behavioral Hypersensitivity through Mitogen-Activated Protein...
GPCR News
Sep 30, 20222 min read
Use of CRISPR/Cas9-edited HEK293 cells reveals that both conventional and novel protein kinase C...
October 2022 Use of CRISPR/Cas9-edited HEK293 cells reveals that both conventional and novel protein kinase C isozymes are involved in...
GPCR News
Sep 30, 20221 min read
N-Acyl Amides from Neisseria meningitidis and Their Role in Sphingosine Receptor Signaling
October 2022 "Neisseria meningitidis is a Gram-negative opportunistic pathogen that is responsible for causing human diseases with high...
GPCR News
Sep 30, 20221 min read
Function and structure of bradykinin receptor 2 for drug discovery
October 2022 "Type 2 bradykinin receptor (B2R) is an essential G protein-coupled receptor (GPCR) that regulates the cardiovascular system...
GPCR News
Sep 30, 20221 min read
Specific Functions of Melanocortin 3 Receptor (MC3R)
October 2022 "Melanocortin 3 receptor (MC3R) is a G-protein coupled receptor (GPCR) that is defined as a regulator of appetite/hunger...
GPCR News
Sep 30, 20221 min read
Viral G Protein-Coupled Receptors Encoded by β- and γ-Herpesviruses
October 2022 "Herpesviruses are ancient large DNA viruses that have exploited gene capture as part of their strategy to escape immune...
GPCR News
Sep 30, 20221 min read
β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the...
October 2022 β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the same GPCR in living cells...
GPCR News
Sep 30, 20221 min read
The complicated lives of GPCRs in cardiac fibroblasts
October 2022 "The role of different G protein-coupled receptors (GPCRs) in the cardiovascular system is well understood in cardiomyocytes...
GPCR News
Sep 30, 20221 min read
Differences across sexes on head-twitch behavior and 5-HT2A receptor signaling in C57BL/6J mice
October 2022 "Psychedelics, also known as classical hallucinogens, affect processes related to perception, cognition and sensory...
GPCR News
Sep 30, 20221 min read
Adrenal G Protein-Coupled Receptors and the Failing Heart: A Long-distance, Yet Intimate Affair
October 2022 "Systolic heart failure (HF) is a chronic clinical syndrome characterized by the reduction in cardiac function and still...
GPCR News
Sep 30, 20222 min read
GB83, an Agonist of PAR2 with a Unique Mechanism of Action Distinct from Trypsin and PAR2-AP
October 2022 "Protease-activated receptor 2 (PAR2) is a G-protein-coupled receptor (GPCR) activated by proteolytic cleavage of its...
GPCR News
Sep 30, 20221 min read
GPR125 (ADGRA3) is an autocleavable adhesion GPCR that traffics with Dlg1 to the basolateral...
October 2022 GPR125 (ADGRA3) is an autocleavable adhesion GPCR that traffics with Dlg1 to the basolateral membrane and regulates...
GPCR News
Sep 30, 20222 min read
Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5
October 2022 "Recently determined structures of class C G protein-coupled receptors (GPCRs) revealed the location of allosteric binding...
GPCR News
Sep 30, 20221 min read
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