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Insights That Move the GPCR Field Forward
Read the latest analyses, interviews, and discoveries shaping the GPCR ecosystem — from research breakthroughs to biotech strategy.
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GPCR Papers
GPCR Papers features curated selections of cutting-edge research advancing receptor biology, pharmacology, and therapeutic innovation. Each post highlights the studies shaping our understanding of GPCRs and their impact across discovery and translational science.
Co-activation of GPCRs facilitate GIRK-dependent current
October 2022 "The activity of dopamine neurons is dependent on both intrinsic properties and afferent projections. One potent form of...
GPCR News
Sep 30, 20222 min read
Label-free LC-MS based assay to characterize small molecule compound binding to cells
October 2022 "Study of small molecule binding to live cells provides important information on the characterization of ligands...
GPCR News
Sep 30, 20221 min read
Cholesterol-Dependent Dynamics of the Serotonin1A Receptor Utilizing Single Particle Tracking: ...
October 2022 Cholesterol-Dependent Dynamics of the Serotonin1A Receptor Utilizing Single Particle Tracking: Analysis of Diffusion Modes...
GPCR News
Sep 30, 20221 min read
G protein-coupled receptor signaling: transducers and effectors
October 2022 "G protein-coupled receptors (GPCRs) are of considerable interest due to their importance in a wide range of physiological...
GPCR News
Sep 30, 20221 min read
Pepducin-mediated G Protein-Coupled Receptor Signaling in the Cardiovascular System
October 2022 "Pepducins are small-lipidated peptides designed from the intracellular loops of G protein-coupled receptors (GPCRs) that...
GPCR News
Sep 30, 20221 min read
Pharmacological targeting of cGAS/STING-YAP axis suppresses pathological angiogenesis and...
October 2022 Pharmacological targeting of cGAS/STING-YAP axis suppresses pathological angiogenesis and ameliorates organ fibrosis "Organ...
GPCR News
Sep 30, 20221 min read
The regulation of PKA signaling in obesity and in the maintenance of metabolic health
October 2022 "The cAMP-dependent protein kinase (PKA) system represents a primary cell-signaling pathway throughout systems and across...
GPCR News
Sep 30, 20221 min read
Protein Uncoupling as an Innovative Practice in Diabetes Mellitus Treatment: A Metabolic Disorder
October 2022 "Background: Uncoupling proteins (UCPs) are unpaired electron carriers that uncouple oxygen intake by the electron transport...
GPCR News
Sep 30, 20221 min read
G protein-biased GPR3 signaling ameliorates amyloid pathology in a preclinical Alzheimer's disease..
October 2022 "Biased G protein-coupled receptor (GPCR) ligands, which preferentially activate G protein or β-arrestin signaling pathways,...
GPCR News
Sep 30, 20221 min read
Bell-Evans model and steered molecular dynamics in uncovering the dissociation kinetics of ligands..
October 2022 Bell-Evans model and steered molecular dynamics in uncovering the dissociation kinetics of ligands targeting...
GPCR News
Sep 30, 20221 min read
Signaling pathways activated by sea bass gonadotropin-inhibitory hormone peptides in COS-7 cells...
September 2022 Signaling pathways activated by sea bass gonadotropin-inhibitory hormone peptides in COS-7 cells transfected with their...
GPCR News
Sep 1, 20221 min read
Expression pattern and clinical significance of beta 2-adrenergic receptor in oral squamous cell...
September 2022 Expression pattern and clinical significance of beta 2-adrenergic receptor in oral squamous cell carcinoma: an emerging...
GPCR News
Aug 31, 20221 min read
Upregulation of Phospholipase C Gene Expression Due to Norepinephrine-Induced Hypertrophic Response
September 2022 "The activation of phospholipase C (PLC) is thought to have a key role in the cardiomyocyte response to several different...
GPCR News
Aug 31, 20221 min read
Fentanyl activates ovarian cancer and alleviates chemotherapy-induced toxicity via opioid...
September 2022 Fentanyl activates ovarian cancer and alleviates chemotherapy-induced toxicity via opioid receptor-dependent activation of...
GPCR News
Aug 31, 20221 min read
Chemerin Forms: Their Generation and Activity
September 2022 "Chemerin is the product of the RARRES2 gene which is secreted as a precursor of 143 amino acids. That precursor is...
GPCR News
Aug 31, 20221 min read
PI(4,5)P 2-stimulated positive feedback drives the recruitment of Dishevelled to Frizzled in Wnt-β-c
September 2022 "In the Wnt-β-catenin pathway, Wnt binding to Frizzled (Fzd) and LRP5 or LRP6 (LRP5/6) co-receptors inhibits the...
GPCR News
Aug 31, 20221 min read
CCL25/CCR9 interaction promotes the malignant behavior of salivary adenoid cystic carcinoma via...
September 2022 CCL25/CCR9 interaction promotes the malignant behavior of salivary adenoid cystic carcinoma via the PI3K/AKT signaling...
GPCR News
Aug 31, 20221 min read
G protein coupling and activation of the metabotropic GABAB heterodimer
September 2022 "Metabotropic γ-aminobutyric acid receptor (GABABR), a class C G protein-coupled receptor (GPCR) heterodimer, plays a...
GPCR News
Aug 31, 20221 min read
GRK3 is a poor prognosticator and serves as a therapeutic target in advanced gastric adenocarcinoma
September 2022 "Background G protein-coupled receptor (GPCR) is the most targeted protein family by the FDA-approved drugs. GPCR-kinase 3...
GPCR News
Aug 31, 20221 min read
Neurotransmitters: Potential Targets in Glioblastoma
September 2022 "For decades, glioblastoma multiforme (GBM), a type of the most lethal brain tumor, has remained a formidable challenge in...
GPCR News
Aug 31, 20221 min read
GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization...
September 2022 GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization, mitochondria-targeting and...
GPCR News
Aug 31, 20221 min read
Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand...
September 2022 Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding...
GPCR News
Aug 31, 20221 min read
Platelets in the NETworks interweaving inflammation and thrombosis
September 2022 "Platelets are well characterized for their indispensable role in primary hemostasis to control hemorrhage. Research over...
GPCR News
Aug 31, 20222 min read
Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane...
September 2022 Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases...
GPCR News
Aug 31, 20221 min read
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