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Insights That Move the GPCR Field Forward
Read the latest analyses, interviews, and discoveries shaping the GPCR ecosystem — from research breakthroughs to biotech strategy.
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GPCR Papers
GPCR Papers features curated selections of cutting-edge research advancing receptor biology, pharmacology, and therapeutic innovation. Each post highlights the studies shaping our understanding of GPCRs and their impact across discovery and translational science.
Regulation of rod photoreceptor function by farnesylated G-protein γ-subunits
September 2022 "Heterotrimeric G-protein transducin, Gt, is a key signal transducer and amplifier in retinal rod and cone photoreceptor...
GPCR News
Aug 31, 20221 min read
Exploiting Dependence of Castration-Resistant Prostate Cancer on the Arginine Vasopressin ...
September 2022 Exploiting Dependence of Castration-Resistant Prostate Cancer on the Arginine Vasopressin Signaling Axis by Repurposing...
GPCR News
Aug 31, 20221 min read
The expression and clinical significance of GPR39 in colon cancer
September 2022 "Background: Colorectal cancer is the third most common cancer and requires more prognostic biomarkers for precise...
GPCR News
Aug 31, 20221 min read
Phosphorylation of RGS regulates MAP kinase localization and promotes completion of cytokinesis
September 2022 "Yeast use the G-protein–coupled receptor signaling pathway to detect and track the mating pheromone. The...
GPCR News
Aug 31, 20221 min read
Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease
September 2022 "Parkinson’s disease (PD) as a progressive neurodegenerative disorder arises from multiple genetic and environmental...
GPCR News
Aug 31, 20221 min read
Interacting binding insights and conformational consequences of the differential activity of...
September 2022 Interacting binding insights and conformational consequences of the differential activity of cannabidiol with two...
GPCR News
Aug 31, 20222 min read
Molecular basis for variations in the sensitivity of pathogenic rhodopsin variants to 9-cis-retinal
September 2022 "Over 100 mutations in the rhodopsin gene have been linked to a spectrum of retinopathies that include retinitis...
GPCR News
Aug 31, 20221 min read
Lysine 101 in the CRAC Motif in Transmembrane Helix 2 Confers Cholesterol-Induced Thermal...
September 2022 Lysine 101 in the CRAC Motif in Transmembrane Helix 2 Confers Cholesterol-Induced Thermal Stability to the Serotonin 1A...
GPCR News
Aug 31, 20221 min read
The Bile Acid Membrane Receptor TGR5 in Cancer: Friend or Foe?
September 2022 "The G-protein-coupled bile acid receptor, Gpbar1 or TGR5, is characterized as a membrane receptor specifically activated...
GPCR News
Aug 31, 20221 min read
Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor
September 2022 "The glucagon-like peptide-1 receptor (GLP-1R) plays a key role in metabolism and is an important therapeutic target in...
GPCR News
Aug 31, 20221 min read
C3aR plays both sides in regulating resistance to bacterial infections
September 2022 "Activation of the complement pathway results in the production of bioactive C3a, a product of C3 cleavage, which...
GPCR News
Aug 31, 20221 min read
Identification and functional characterization of the sulfakinin and sulfakinin receptor in the...
September 2022 Identification and functional characterization of the sulfakinin and sulfakinin receptor in the Chinese white pine beetle...
GPCR News
Aug 31, 20221 min read
Sweet taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation...
September 2022 Sweet taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation linked to autophagy...
GPCR News
Aug 31, 20221 min read
Dynamic recognition of naloxone, morphine and endomorphin1 in the same pocket of µ-opioid receptors
September 2022 "Morphine, the most widely used analgesic, relieves severe pain by activating the μ-opioid receptor (MOR), whereas...
GPCR News
Aug 31, 20221 min read
Functional Characterization of the Venus Flytrap Domain of the Human TAS1R2 Sweet Taste Receptor
September 2022 "The human sweet taste receptor is a heterodimeric receptor composed of two distinct G-protein-coupled receptors (GPCRs),...
GPCR News
Aug 31, 20222 min read
Combined docking and machine learning identify key molecular determinants of ligand pharmacological
September 2022 "G protein‐coupled receptors (GPCRs) are valuable therapeutic targets for many diseases. A central question of GPCR drug...
GPCR News
Aug 31, 20221 min read
Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota..
September 2022 Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota, and T cell-induced...
GPCR News
Aug 31, 20221 min read
Targeting mGluR2/3 for treatment of neurodegenerative and neuropsychiatric diseases
September 2022 "Glutamate is the primary excitatory neurotransmitter in the brain and plays critical roles in all aspects of neuronal...
GPCR News
Aug 31, 20221 min read
Identification of hub genes in the subacute spinal cord injury in rats
September 2022 "Background Spinal cord injury (SCI) is a common trauma in clinical practices. Subacute SCI is mainly characterized by...
GPCR News
Aug 31, 20221 min read
Endogenous ligand recognition and structural transition of a human PTH receptor
September 2022 "Endogenous parathyroid hormone (PTH) and PTH-related peptide (PTHrP) bind to the parathyroid hormone receptor 1 (PTH1R)...
GPCR News
Aug 31, 20221 min read
CD28 and chemokine receptors: Signalling amplifiers at the immunological synapse
September 2022 "T cells are master regulators of the immune response tuning, among others, B cells, macrophages and NK cells. To exert...
GPCR News
Aug 31, 20221 min read
Serotonin Receptor 5-HT2A Regulates TrkB Receptor Function in Heteroreceptor Complexes
September 2022 "Serotonin receptor 5-HT2A and tropomyosin receptor kinase B (TrkB) strongly contribute to neuroplasticity regulation and...
GPCR News
Aug 31, 20221 min read
PAR-Induced Harnessing of EZH2 to β-Catenin: Implications for Colorectal Cancer
September 2022 "G-protein-coupled receptors (GPCRs) are involved in a wide array of physiological and disease functions, yet knowledge of...
GPCR News
Aug 31, 20221 min read
Endocannabinoid System in the Neuroendocrine Response to Lipopolysaccharide-induced Immune Challenge
September 2022 "The endocannabinoid system plays a key role in the intersection of the nervous, endocrine, and immune systems, regulating...
GPCR News
Aug 31, 20221 min read
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