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Insights That Move the GPCR Field Forward
Read the latest analyses, interviews, and discoveries shaping the GPCR ecosystem — from research breakthroughs to biotech strategy.
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GPCR Papers
GPCR Papers features curated selections of cutting-edge research advancing receptor biology, pharmacology, and therapeutic innovation. Each post highlights the studies shaping our understanding of GPCRs and their impact across discovery and translational science.
Addex and Indivior Extend GABAB Positive Allosteric Modulator Research Collaboration for...
August 2022 Addex and Indivior Extend GABAB Positive Allosteric Modulator Research Collaboration for Substance Use Disorders "Geneva,...
GPCR News
Jul 31, 20221 min read
Gαs and Gαq/11 protein coupling bias of two AVPR2 mutants (R68W and V162A) that cause nephrogenic di
August 2022 Gαs and Gαq/11 protein coupling bias of two AVPR2 mutants (R68W and V162A) that cause nephrogenic diabetes insipidus...
GPCR News
Jul 31, 20221 min read
The NPXXY Motif Regulates β-Arrestin Recruitment by the CB1 Cannabinoid Receptor
August 2022 "Background: Activation of signaling effectors by G-protein coupled receptors (GPCRs) depends on different molecular...
GPCR News
Jul 31, 20221 min read
G protein-coupled receptor 21 in macrophages: An in vitro study
August 2022 "GPR21 is an orphan and constitutively active receptor belonging to the superfamily of G-Protein Coupled Receptors (GPCRs)....
GPCR News
Jul 31, 20221 min read
MSX-122: Is an effective small molecule CXCR4 antagonist in cancer therapy?
August 2022 "Chemokines, a subgroup of cytokines along with their receptors, are involved in various biologic processes and regulation of...
GPCR News
Jul 31, 20221 min read
Fusion protein strategies for cryo-EM study of G protein-coupled receptors
August 2022 "Single particle cryogenic-electron microscopy (cryo-EM) is used extensively to determine structures of activated G...
GPCR News
Jul 31, 20221 min read
Addex Reports 2022 Half Year and Second Quarter Financial Results and Provides Corporate Update
August 2022 "Geneva, Switzerland, August 18, 2022 - Addex Therapeutics (SIX and Nasdaq: ADXN), a clinical-stage pharmaceutical company...
GPCR News
Jul 31, 20221 min read
GPR3 expression in retinal ganglion cells contributes to neuron survival and accelerates axonal...
August 2022 GPR3 expression in retinal ganglion cells contributes to neuron survival and accelerates axonal regeneration after optic...
GPCR News
Jul 31, 20222 min read
Diversity and specificity in location-based signaling outputs of neuronal GPCRs
August 2022 "The common mechanisms by which members of the G protein-coupled receptor (GPCR) family respond to neurotransmitters in the...
GPCR News
Jul 31, 20221 min read
Posttranslational modifications in GPCR internalization
August 2022 "G protein-coupled receptors (GPCRs) are the largest family of membrane receptors that serve as the most important drug...
GPCR News
Jul 31, 20221 min read
Molecular basis for ligand modulation of the cannabinoid CB 1 receptor
August 2022 "The cannabinoid CB1 receptor is the most abundant G protein coupled receptor (GPCR) in the central nervous system, which...
GPCR News
Jul 31, 20221 min read
In vivo detection of GPCR-dependent signaling using fiber photometry and FRET-based biosensors
August 2022 "Genetically encoded fluorescent biosensors allow intracellular signaling dynamics to be tracked in live cells and tissues...
GPCR News
Jul 31, 20221 min read
GRK2 in cardiovascular disease and its potential as a therapeutic target
August 2022 "Cardiovascular diseases (CVDs) represent the leading cause of death globally. Despite major advances in the field of...
GPCR News
Jul 31, 20221 min read
Targeting CXCR1 and CXCR2 receptors in cardiovascular diseases
August 2022 "CXCR1 and CXCR2 chemokine receptors, mainly activated by interleukin 8 (IL-8 or CXCL8), are expressed in a variety of cells...
GPCR News
Jul 31, 20221 min read
TAS2R supports odontoblastic differentiation of human dental pulp stem cells in the inflammatory...
August 2022 TAS2R supports odontoblastic differentiation of human dental pulp stem cells in the inflammatory microenvironment...
GPCR News
Jul 31, 20221 min read
Adenosine receptor signalling in Alzheimer's disease
August 2022 "Alzheimer's disease (AD) is the most common dementia in the elderly and its increasing prevalence presents treatment...
GPCR News
Jul 31, 20221 min read
Structures of β 1-adrenergic receptor in complex with Gs and ligands of different efficacies
August 2022 "G-protein-coupled receptors (GPCRs) receive signals from ligands with different efficacies, and transduce to heterotrimeric...
GPCR News
Jul 31, 20221 min read
Exploring pharmacological inhibition of G q/11 as an analgesic strategy
August 2022 "Background and purpose: Misuse of opioids has greatly affected our society. One potential solution is to develop analgesics...
GPCR News
Jul 31, 20221 min read
Anatomy of a partnership: Cancer Research UK teams up with Sosei Heptares
August 2022 "August 10, 2022 Cancer Research UK is working with global biopharma Sosei Heptares on a treatment they hope will bring...
GPCR News
Jul 31, 20221 min read
Fluorescent Ligands Targeting Intracellular Allosteric Binding Site of the Chemokine Receptor CCR2
August 2022 "Fluorescently labeled ligands are versatile molecular tools to study G protein-coupled receptors (GPCRs) and can be used for...
GPCR News
Jul 31, 20221 min read
Karuna Therapeutics Announces Positive Results from Phase 3 EMERGENT-2 Trial of KarXT in...
August 2022 Karuna Therapeutics Announces Positive Results from Phase 3 EMERGENT-2 Trial of KarXT in Schizophrenia "BOSTON--(BUSINESS...
GPCR News
Jul 31, 20221 min read
Synthesis and characterization of an orally bioavailable small molecule agonist of the apelin recept
August 2022 "The apelin receptor (APJ) is a target for cardiovascular indications. Previously, we had identified a novel pyrazole-based...
GPCR News
Jul 31, 20221 min read
Luciferase-based GloSensorâ„¢ cAMP assay: Temperature optimization and application to cell-based kinet
August 2022 Luciferase-based GloSensorâ„¢ cAMP assay: Temperature optimization and application to cell-based kinetic studies "G...
GPCR News
Jul 31, 20221 min read
Tracking receptor motions at the plasma membrane reveals distinct effects of ligands on CCR5...
August 2022 "G-protein-coupled receptors (GPCR) are present at the cell surface in different conformational and oligomeric states....
GPCR News
Jul 31, 20221 min read
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