In Terry Kenakin’s latest foundational lesson from Terry’s Corner, he unpacks the art and science of pharmacologic modeling. This isn’t just theory—it's the essential framework used to interpret experimental data, anticipate system-wide drug effects, and design smarter trials.

In this lesson, Terry Kenakin dismantles 100 years of receptor theory and introduces you to a dynamic new framework: Molecular Dynamics. Discover how receptors actually behave, how ligands uniquely sculpt their function, and how cryptic allosteric sites are quietly reshaping the frontier of drug discovery.

In this eye-opening module, Terry Kenakin explores a concept that could change how you interpret pharmacological data: the interplay between intrinsic efficacy and system sensitivity. It’s not just about what your molecule does—it’s also about how capable your system is at showing it.

This isn’t just a theory class. Terry walks you through real-world experiments, decades of receptor pharmacology wisdom, and the cutting-edge operational model used to quantify efficacy. You'll learn why some agonists succeed in sensitive tissues but fail elsewhere—and how this knowledge can dramatically shift your screening strategy.

In this foundational lesson, Terry Kenakin dives deep into a widely used, often misunderstood tool in early drug discovery: the calcium assay. Revered for its convenience, the FLIPR assay provides rapid insights into receptor activity. But its speed comes with a cost.

Join Terry Kenakin as he pulls back the curtain on the deceptively simple process of orthosteric binding—the first step in drug action. This isn’t just about molecules finding a pocket. It’s about a dynamic dance of chemical forces, equilibrium shifts, and molecular decisions that determine whether a compound works… or doesn’t.

In the newest foundational lesson from Terry Kenakin’s Pharmacology Vault, we unlock the visual language of pharmacology: dose-response curves. From assessing drug potency to predicting effects, these curves aren't just for data—they’re your entry point to understanding drug behavior at a deeper level.

In this exclusive foundational-level lecture, Dr. Terry Kenakin takes you on a captivating tour through the history of pharmacology: a journey that spans ancient Egypt, revolutionary scientific ideas, Nobel Prize-winning discoveries, and today's digital frontier. But this isn't just about what was—it's about why the past matters now.

In his newest lesson, “The Uniqueness of Pharmacology in Drug Discovery,” Terry Kenakin explains why pharmacology isn’t a clean-cut science—it’s a dynamic dialogue between molecule and system.

In this foundational-level lesson, Terry unpacks the real-life process behind discovering new drugs, breaking down the science into accessible, engaging insights for early learners and curious minds.

In the foundational lesson of Terry’s Corner, Dr. Terry Kenakin invites us to challenge outdated assumptions and step into a new era of drug discovery.