Integration and Spatial Organization of Signaling by G Protein-Coupled Receptor Homo- and Heterodimer Information flow from a source to a...

Humanity has always sought to live longer and for this, multiple strategies have been tried with varying results. In this sense, G...

Chemical communication controls a wide range of behaviors via conserved signaling networks. Axon regeneration in response to injury is...

HDX-MS-optimized approach to characterize nanobodies as tools for biochemical and structural studies of class IB phosphoinositide...

"The effects of the neurohormone melatonin are mediated by the activation of the GPCRs MT1 and MT2 in a variety of tissues. Crystal...

Obesity-induced changes in human islet G protein-coupled receptor expression: Implications for metabolic regulation G protein-coupled...

"We are moving ahead with SLAS2022 as an in-person event with a hybrid component. We are closely monitoring any regulation changes from...

December 2021 "Drug development is rarely trivial. In fact, it is often costly, frustrating, and tortuous—and more often than not it...

The mammalian target of rapamycin (mTOR) senses upstream stimuli to regulate numerous cellular functions such as metabolism, growth, and...

Involvement of various chemokine/chemokine receptor axes in trafficking and oriented locomotion of mesenchymal stem cells in multiple...

Neuronal Gα subunits required for the control of response to polystyrene nanoparticles in the range of μg/L in C. elegans The aim of this...

APRIL 06 - 09, 2022 | | SNOWBIRD RESORT, UTAH, UNITED STATES The superfamily of G protein-coupled receptors (GPCRs) act as molecular...

December 2021 "Dame Carol Robinson DBE, FRS, FRSC, FMedSci, Oxford University’s first female Professor of Chemistry, former president of...

G protein-coupled receptors (GPCRs) transmit extracellular signals to the inside by activation of intracellular effector proteins....

Phenylalanine 193 in Extracellular Loop 2 of the β 2-Adrenergic Receptor Coordinates β-Arrestin Interaction G protein-coupled receptors...

Exendin-4 Attenuates Remodeling in the Remote Myocardium of Rats After an Acute Myocardial Infarction by Activating β-Arrestin-2, Protein...

Mutations in G protein-coupled receptors (GPCRs) underlie numerous diseases. Many cause receptor misfolding and failure to reach the cell...

Until recently, itch pathophysiology was poorly understood and treatments were poorly effective in relieving itch. Current progress in...

Nuclear magnetic resonance (NMR) spectroscopy allows the determination of atomic-level information on intermolecular interactions,...

SEPTEMBER 26-29, 2022 (Leipzig, Germany)​ 4GPCRnet meeting bringing together four of the biggest GPCR networks in Europe for a joint...

Biased pharmacological modulators provide potential therapeutic benefits, including greater pharmacodynamic specificity, increased...

December 2021 "Meet Peter McNamara, Ph.D., Tectonic’s SVP, Head of Research. Peter joined Tectonic to help chart new territory in GPCR...

Lysophosphatidic acids (LPAs) are bioactive phospholipids implicated in a wide range of cellular activities that regulate a diverse array...

Coordinated transcriptomics and peptidomics of central nervous system identify neuropeptides and their G protein-coupled receptors in the...