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Insights That Move the GPCR Field Forward
Read the latest analyses, interviews, and discoveries shaping the GPCR ecosystem — from research breakthroughs to biotech strategy.
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Pharmacological Properties and Function of PxOctβ3 Octopamine Receptor in Plutella xylostella (L.)
September 2022 "The diamondback moth (Plutella xylostella) is one of the most destructive lepidopteran pests of cruciferous vegetables,...

GPCR News
Sep 1, 20221 min read
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Effect Delta-9-tetrahydrocannabinol and cannabidiol on milk proteins and lipid levels in HC11 cells
September 2022 "Pregnant and lactating women have been discouraged from using cannabis by Health Canada. However, the increasing rate of...

GPCR News
Sep 1, 20221 min read
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GASP1 enhances malignant phenotypes of breast cancer cells and decreases their response to...
September 2022 GASP1 enhances malignant phenotypes of breast cancer cells and decreases their response to paclitaxel by forming a vicious...

GPCR News
Sep 1, 20221 min read
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Hear the sounds: the role of G protein-coupled receptors in the cochlea
September 2022 "Sound is converted by hair cells in the cochlea into electrical signals, which are transmitted by spiral ganglion neurons...

GPCR News
Sep 1, 20221 min read
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Novel Driver Strength Index highlights important cancer genes in TCGA PanCanAtlas patients
September 2022 "Background Cancer driver genes are usually ranked by mutation frequency, which does not necessarily reflect their driver...

GPCR News
Sep 1, 20221 min read
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Structural basis for receptor selectivity and inverse agonism in S1P5 receptors
September 2022 "The bioactive lysophospholipid sphingosine-1-phosphate (S1P) acts via five different subtypes of S1P receptors (S1PRs) -...

GPCR News
Sep 1, 20221 min read
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Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify...
September 2022 Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify receptor-transducer coupling and...

GPCR News
Sep 1, 20221 min read
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Roles of Focal Adhesion Kinase PTK2 and Integrin αIIbβ3 Signaling in Collagen- and GPVI-Dependent...
September 2022 Roles of Focal Adhesion Kinase PTK2 and Integrin αIIbβ3 Signaling in Collagen- and GPVI-Dependent Thrombus Formation under...

GPCR News
Sep 1, 20221 min read
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Cell Surface Calcium-Sensing Receptor Heterodimers: Mutant Gene Dosage Affects Ca 2+ Sensing but...
September 2022 Cell Surface Calcium-Sensing Receptor Heterodimers: Mutant Gene Dosage Affects Ca 2+ Sensing but Not G Protein Interaction...

GPCR News
Sep 1, 20222 min read
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A Setmelanotide-like Effect at MC4R Is Achieved by MC4R Dimer Separation
September 2022 "Melanocortin 4 receptor (MC4R) is part of the leptin-melanocortin pathway and plays an essential role in mediating energy...

GPCR News
Sep 1, 20221 min read
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High GPER expression in triple-negative breast cancer is linked to pro-metastatic pathways and...
September 2022 High GPER expression in triple-negative breast cancer is linked to pro-metastatic pathways and predicts poor patient...

GPCR News
Sep 1, 20221 min read
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A broad look into the future of systemic sclerosis
September 2022 "Systemic sclerosis (SSc) is a systemic autoimmune disease with the key features of inflammation, vasculopathy and...

GPCR News
Sep 1, 20221 min read
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Ligands can differentially and temporally modulate GPCR interaction with 14-3-3 isoforms
September 2022 "GPCR signaling and function depend on their associated proteins and subcellular locations. Besides G-proteins and...

GPCR News
Sep 1, 20221 min read
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GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation
September 2022 GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation in macrophages "The...

GPCR News
Sep 1, 20221 min read
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Fly casting with ligand sliding and orientational selection supporting complex formation of a GPCR..
September 2022 Fly casting with ligand sliding and orientational selection supporting complex formation of a GPCR and a middle sized...

GPCR News
Sep 1, 20221 min read
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Dimerization of GPCRs: Novel insight into the role of FLNA and SSAs regulating SST2 and SST5...
September 2022 Dimerization of GPCRs: Novel insight into the role of FLNA and SSAs regulating SST2 and SST5 homo- and hetero-dimer...

GPCR News
Sep 1, 20222 min read
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Cholesterol occupies the lipid translocation pathway to block phospholipid scrambling by a GPCR
September 2022 "Class A (rhodopsin-like) G protein-coupled receptors (GPCRs) are constitutive phospholipid scramblases as evinced after...

GPCR News
Sep 1, 20221 min read
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Integrative model of the FSH receptor reveals the structural role of the flexible hinge region
September 2022 "The follicle-stimulating hormone receptor (FSHR) belongs to the glycoprotein hormone receptors, a subfamily of...

GPCR News
Sep 1, 20221 min read
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Angiotensin-(1-7) improves cognitive function and reduces inflammation in mice following mild trauma
September 2022 Angiotensin-(1-7) improves cognitive function and reduces inflammation in mice following mild traumatic brain injury...

GPCR News
Sep 1, 20221 min read
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Molecular insights into regulation of constitutive activity by RNA editing 5HT2C serotonin receptor
September 2022 "RNA editing is a process by which post-transcriptional changes of mRNA nucleotides alter protein function through...

GPCR News
Sep 1, 20221 min read
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PLC-IP3-ORAI pathway participates in the activation of the MRGPRB2 receptor in mouse peritoneal...
September 2022 PLC-IP3-ORAI pathway participates in the activation of the MRGPRB2 receptor in mouse peritoneal mast cells "A novel mast...

GPCR News
Sep 1, 20221 min read
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Exploiting Dependence of Castration-Resistant Prostate Cancer on the Arginine Vasopressin ...
September 2022 Exploiting Dependence of Castration-Resistant Prostate Cancer on the Arginine Vasopressin Signaling Axis by Repurposing...

GPCR News
Sep 1, 20221 min read
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The expression and clinical significance of GPR39 in colon cancer
September 2022 "Background: Colorectal cancer is the third most common cancer and requires more prognostic biomarkers for precise...

GPCR News
Sep 1, 20221 min read
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Phosphorylation of RGS regulates MAP kinase localization and promotes completion of cytokinesis
September 2022 "Yeast use the G-protein–coupled receptor signaling pathway to detect and track the mating pheromone. The...

GPCR News
Sep 1, 20221 min read
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