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Insights That Move the GPCR Field Forward
Read the latest analyses, interviews, and discoveries shaping the GPCR ecosystem — from research breakthroughs to biotech strategy.
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Expression pattern and clinical significance of beta 2-adrenergic receptor in oral squamous cell...
September 2022 Expression pattern and clinical significance of beta 2-adrenergic receptor in oral squamous cell carcinoma: an emerging...

GPCR News
Aug 31, 20221 min read
PI(4,5)P 2-stimulated positive feedback drives the recruitment of Dishevelled to Frizzled in Wnt-β-c
September 2022 "In the Wnt-β-catenin pathway, Wnt binding to Frizzled (Fzd) and LRP5 or LRP6 (LRP5/6) co-receptors inhibits the...

GPCR News
Aug 31, 20221 min read
CCL25/CCR9 interaction promotes the malignant behavior of salivary adenoid cystic carcinoma via...
September 2022 CCL25/CCR9 interaction promotes the malignant behavior of salivary adenoid cystic carcinoma via the PI3K/AKT signaling...

GPCR News
Aug 31, 20221 min read
G protein coupling and activation of the metabotropic GABAB heterodimer
September 2022 "Metabotropic γ-aminobutyric acid receptor (GABABR), a class C G protein-coupled receptor (GPCR) heterodimer, plays a...

GPCR News
Aug 31, 20221 min read
GRK3 is a poor prognosticator and serves as a therapeutic target in advanced gastric adenocarcinoma
September 2022 "Background G protein-coupled receptor (GPCR) is the most targeted protein family by the FDA-approved drugs. GPCR-kinase 3...

GPCR News
Aug 31, 20221 min read
Cell-Type-Specific Effects of the Ovarian Cancer G-Protein Coupled Receptor (OGR1) on Inflammation..
September 2022 Cell-Type-Specific Effects of the Ovarian Cancer G-Protein Coupled Receptor (OGR1) on Inflammation and Fibrosis; Potential...

GPCR News
Aug 31, 20221 min read
The Gluopsins: Opsins without the Retinal Binding Lysine
September 2022 "Opsins allow us to see. They are G-protein-coupled receptors and bind as ligand retinal, which is bound covalently to a...

GPCR News
Aug 31, 20221 min read
Multifunctional role of GPCR signaling in epithelial tube formation
September 2022 "Epithelial tube formation requires Rho1-dependent actomyosin contractility to generate the cellular forces that drive...

GPCR News
Aug 31, 20221 min read
Neuropeptide S Encodes Stimulus Salience in the Paraventricular Thalamus
September 2022 "Evaluation of stimulus salience is critical for any higher organism, as it allows for prioritizing of vital information,...

GPCR News
Aug 31, 20221 min read
Endothelin-1 Stimulates PAI-1 Protein Expression via Dual Transactivation Pathway Dependent ROCK...
September 2022 Endothelin-1 Stimulates PAI-1 Protein Expression via Dual Transactivation Pathway Dependent ROCK and Phosphorylation of...

GPCR News
Aug 31, 20221 min read
Lack of Oestrogen Receptor Expression in Breast Cancer Cells Does Not Correlate with Kisspeptin...
September 2022 Lack of Oestrogen Receptor Expression in Breast Cancer Cells Does Not Correlate with Kisspeptin Signalling and Migration...

GPCR News
Aug 31, 20221 min read
Regulator of G Protein Signaling 20 Correlates with Long Intergenic Non-Coding RNA (lincRNAs)...
September 2022 Regulator of G Protein Signaling 20 Correlates with Long Intergenic Non-Coding RNA (lincRNAs) Harboring Oncogenic...

GPCR News
Aug 31, 20221 min read
Pharmacological Properties and Function of PxOctβ3 Octopamine Receptor in Plutella xylostella (L.)
September 2022 "The diamondback moth (Plutella xylostella) is one of the most destructive lepidopteran pests of cruciferous vegetables,...

GPCR News
Aug 31, 20221 min read
Effect Delta-9-tetrahydrocannabinol and cannabidiol on milk proteins and lipid levels in HC11 cells
September 2022 "Pregnant and lactating women have been discouraged from using cannabis by Health Canada. However, the increasing rate of...

GPCR News
Aug 31, 20221 min read
GASP1 enhances malignant phenotypes of breast cancer cells and decreases their response to...
September 2022 GASP1 enhances malignant phenotypes of breast cancer cells and decreases their response to paclitaxel by forming a vicious...

GPCR News
Aug 31, 20221 min read
Hear the sounds: the role of G protein-coupled receptors in the cochlea
September 2022 "Sound is converted by hair cells in the cochlea into electrical signals, which are transmitted by spiral ganglion neurons...

GPCR News
Aug 31, 20221 min read
Novel Driver Strength Index highlights important cancer genes in TCGA PanCanAtlas patients
September 2022 "Background Cancer driver genes are usually ranked by mutation frequency, which does not necessarily reflect their driver...

GPCR News
Aug 31, 20221 min read
Structural basis for receptor selectivity and inverse agonism in S1P5 receptors
September 2022 "The bioactive lysophospholipid sphingosine-1-phosphate (S1P) acts via five different subtypes of S1P receptors (S1PRs) -...

GPCR News
Aug 31, 20221 min read
Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify...
September 2022 Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify receptor-transducer coupling and...

GPCR News
Aug 31, 20221 min read
Roles of Focal Adhesion Kinase PTK2 and Integrin αIIbβ3 Signaling in Collagen- and GPVI-Dependent...
September 2022 Roles of Focal Adhesion Kinase PTK2 and Integrin αIIbβ3 Signaling in Collagen- and GPVI-Dependent Thrombus Formation under...

GPCR News
Aug 31, 20221 min read
Cell Surface Calcium-Sensing Receptor Heterodimers: Mutant Gene Dosage Affects Ca 2+ Sensing but...
September 2022 Cell Surface Calcium-Sensing Receptor Heterodimers: Mutant Gene Dosage Affects Ca 2+ Sensing but Not G Protein Interaction...

GPCR News
Aug 31, 20222 min read
A Setmelanotide-like Effect at MC4R Is Achieved by MC4R Dimer Separation
September 2022 "Melanocortin 4 receptor (MC4R) is part of the leptin-melanocortin pathway and plays an essential role in mediating energy...

GPCR News
Aug 31, 20221 min read
High GPER expression in triple-negative breast cancer is linked to pro-metastatic pathways and...
September 2022 High GPER expression in triple-negative breast cancer is linked to pro-metastatic pathways and predicts poor patient...

GPCR News
Aug 31, 20221 min read
A broad look into the future of systemic sclerosis
September 2022 "Systemic sclerosis (SSc) is a systemic autoimmune disease with the key features of inflammation, vasculopathy and...

GPCR News
Aug 31, 20221 min read
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