Comparative studies of AlphaFold, RoseTTAFold and Modeller: a case study involving the use of...
October 2022 Comparative studies of AlphaFold, RoseTTAFold and Modeller: a case study involving the use of G-protein-coupled receptors...
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The Adhesion GPCR VLGR1/ADGRV1 Regulates the Ca2+ Homeostasis at Mitochondria-Associated ER Membrane
October 2022 "The very large G protein-coupled receptor (VLGR1, ADGRV1) is the largest member of the adhesion GPCR family. Mutations in...
Mechanism of enhanced sensitivity of mutated β-adrenergic-like octopamine receptor to amitraz in...
October 2022 Mechanism of enhanced sensitivity of mutated β-adrenergic-like octopamine receptor to amitraz in honeybee Apis mellifera: An...
Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental...
October 2022 Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental development and preeclampsia...
Enhanced membrane binding of oncogenic G protein αqQ209L confers resistance to inhibitor YM-254890
October 2022 "Heterotrimeric G proteins couple activated G protein-coupled receptors (GPCR) to intracellular signaling pathways. They can...
N-terminal alterations turn the gut hormone GLP-2 into an antagonist with gradual loss of GLP-2 ...
October 2022 N-terminal alterations turn the gut hormone GLP-2 into an antagonist with gradual loss of GLP-2 receptor selectivity towards...
GPR15 expressed in T lymphocytes from RA patients is involved in leukocyte chemotaxis to the...
October 2022 GPR15 expressed in T lymphocytes from RA patients is involved in leukocyte chemotaxis to the synovium "The rheumatoid...
PH-Binding Motif in PAR4 Oncogene: From Molecular Mechanism to Drug Design
October 2022 "While the role of G-protein-coupled receptors (GPCR) in cancer is acknowledged, their underlying signaling pathways are...
Single-molecule counting applied to the study of GPCR oligomerization
October 2022 "Single-molecule counting techniques enable a precise determination of the intracellular abundance and stoichiometry of...
Membrane Lipids Are an Integral Part of Transmembrane Allosteric Sites in GPCRs: A Case Study of...
October 2022 Membrane Lipids Are an Integral Part of Transmembrane Allosteric Sites in GPCRs: A Case Study of Cannabinoid CB1 Receptor...
Dopamine activates astrocytes in prefrontal cortex via α1-adrenergic receptors
October 2022 "The prefrontal cortex (PFC) is a hub for cognitive control, and dopamine profoundly influences its functions. In other...
Novel Therapies for Cardiometabolic Disease: Recent Findings in Studies with Hormone...
October 2022 Novel Therapies for Cardiometabolic Disease: Recent Findings in Studies with Hormone Peptide-Derived G Protein Coupled...
Advancements in G protein-coupled receptor biosensors to study GPCR-G protein coupling
October 2022 "Enzymatic and cellular signalling biosensors are used to decipher the activities of complex biological systems. Biosensors...
Network pharmacological investigation into the mechanism of Kaixinsan powder for the treatment of...
October 2022 Network pharmacological investigation into the mechanism of Kaixinsan powder for the treatment of depression "Kaixinsan...
Diversification of PAR signaling through receptor crosstalk
October 2022 "Protease activated receptors (PARs) are among the first receptors shown to transactivate other receptors: noticeably, these...
Comparative study of neuropeptide signaling systems in Hemiptera
October 2022 "Numerous physiological processes in insects are tightly regulated by neuropeptides and their receptors. Although they form...
Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1
October 2022 "Lysosomes coordinate cellular metabolism and growth upon sensing of essential nutrients, including cholesterol. Through...
Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered agonist...
October 2022 Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered agonist-mediated activation...
A cryptic mode of GPCR regulation revealed
October 2022 "Over three decades of research have provided thorough insights into G protein-coupled receptor (GPCR) regulation. In a...
Design and validation of recombinant protein standards for quantitative Western blot analysis of...
October 2022 Design and validation of recombinant protein standards for quantitative Western blot analysis of cannabinoid CB1 receptor...
Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi...
October 2022 Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi by macrophages "The fungal...
Successful prednisolone or calcimimetic treatment of acquired hypocalciuric hypercalcemia caused...
October 2022 Successful prednisolone or calcimimetic treatment of acquired hypocalciuric hypercalcemia caused by biased allosteric CaSR...
Developing the Cannabinoid Receptor 2 (CB2) pharmacopoeia: past, present, and future
October 2022 "Cannabinoid Receptor 2 (CB2) is a G protein-coupled receptor (GPCR) with considerable, though as yet unrealised,...
The microglial endocannabinoid system similarly regulated by lipopolysaccharide and interferon gamma
October 2022 "Perturbation of the endocannabinoid system can have profound effects on immune function and synaptic plasticity. Microglia...
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